Paper Title
Antiviral Potential of Swida Darvasica Extracts Against Influenza a Virus Strains

Abstract
Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Many medicinal properties of plants have not yet been thoroughly studied in particular endemic species. It is known that the influenza virus has a high mutational variability, contributing to the rapid acquisition of drug resistance, reduces or nullifies the effectiveness of existing treatment methods, thereby necessitating the search for new therapeutic agents. This study examined the effects of antiviral activity of Swida darvasica - endemic to Tajikistan. (ethanol extraction). Еxtract Swida darvasica were tested against two antigenic formula of the influenza virus: A/Vladivostok/2/09 (H1N1) and A/Almaty/8/98 (H3N2). Notably, the fruits extract this plant a demonstrated significant antiviral activity against both influenza virus strains tested. The antiviral effect of this extract was characterized by exceptionally high EC50 and SI values, superior to those of the reference drug Tamiflu. These results indicate that Swida darvasica promising potential for the development of new effective antiviral agents against influenza.Comparative analyses included the well-known anti-influenza medications Tamiflu, which served as positive controls due to their low IC50 values and broad-spectrum antiviral capabilities. Keywords - Swida Darvasica, Influenza Viruses, IC50, EC50, IS50